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Research in sleep-disordered breathing (SDB)

Through Resmed’s strong partnerships within the global medical community, we are committed to supporting and engaging in SDB research that:

  • leverages real-world evidence (RWE) to gain new perspectives on SDB patients’ responses and outcomes
  • investigates the benefits of digital health technologies to support therapy adherence
  • evaluates the efficacy of OSA therapies

Real-world evidence studies focusing on PAP therapy for OSA patients

ALASKA study outcomes: first publication1

The first outcomes from the ALASKA study showed that it’s important to consider patient phenotyping and personalised care when developing integrated sleep apnoea management strategies.

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ALASKA study results: second and third publication2,3

Outcomes from the ALASKA study found that not only does the chance of survival increase by 39% if PAP therapy is continued for the first year, there are also survival benefits for patients who resume CPAP after an initial discontinuation.

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PATHOS: Prevalence and predictors of PAP usage in OSA4

This German retrospective study of 22,317 obstructive sleep apnoea patients found only 55% of all eligible patients were prescribed PAP therapy. It highlighted the significant predictors of PAP treatment.
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Obstructive sleep apnoea research

Sleep apnoea and digital connected health

Improved compliance, greater efficiencies, higher quality of care – here is some of the latest research that provides evidence of these results.

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Narval CC*

There’s a growing body of clinical research that demonstrates the efficacy and compliance of mandibular repositioning devices (MRDs) in treating obstructive sleep apnoea and snoring.

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Research in ASV therapy

There is increasing evidence to suggest that adaptive servo-ventilation (ASV) therapy can be effective in the eligible central sleep apnoea (CSA) population. We’ve collated the key clinical studies and guidelines on the use of ASV to give you the big picture of this therapy in practice and its potential benefits for patients.

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Support for investigator initiated research

Resmed believes in the need to support ethical, independent clinical research, conducted by qualified third-party investigators.

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* Please note the Narval CC mandibular advancement device is not available in England, Scotland or Wales.

Narval CC is indicated to treat adults with snoring or mild to moderate obstructive sleep apnoea (OSA). In cases of severe OSA, it is indicated after continuous positive airway pressure (CPAP) therapy failure, non-compliance or refusal.

This content is intended for health professionals only. Please refer to the instructions for use for relevant information related to any warnings and precautions to be considered before and during use of the product.

References:
  1. Pépin, J.-L.; Bailly, S.; Rinder, P.; Adler, D.; Szeftel, D.; Malhotra, A.; Cistulli, P.A.; Benjafield, A.; Lavergne, F.; Josseran, ; et al. CPAP Therapy Termination Rates by OSA Phenotype: A French Nationwide Database Analysis. J. Clin. Med. 2021, 10, 936. https://doi.org/10.3390/jcm10050936
    Retrospective analysis on 480 000 adult patients with CPAP therapy initiated from 2015 to end of 2016, identified in the French Health insurance claims database, and followed up until end of 2019
  2. Pépin JL et al. Relationship Between CPAP Termination and All-Cause Mortality: A French Nationwide Database Analysis. Chest. 2022 Jun;161(6):1657-1665. doi: 10.1016/j.chest.2022.02.013.
  3. Pépin JL et al. CPAP resumption after a first termination and impact on all-cause mortality in France. Eur Respir J. 2024 Feb 1;63(2):2301171. doi: 10.1183/13993003.01171-2023.
  4. Woehrle, H., Arzt, M., Ficker, J.H. et al. Prevalence and predictors of positive airway pressure therapy prescription in obstructive sleep apnoea: a population-representative study. Somnologie (2023). https://doi.org/10.1007/s11818-023-00435-2

Last update: 06/2024